Switch NFix Developmental Myogenesis
نویسندگان
چکیده
منابع مشابه
Nfix Regulates Fetal-Specific Transcription in Developing Skeletal Muscle
Skeletal myogenesis, like hematopoiesis, occurs in successive developmental stages that involve different cell populations and expression of different genes. We show here that the transcription factor nuclear factor one X (Nfix), whose expression is activated by Pax7 in fetal muscle, in turn activates the transcription of fetal specific genes such as MCK and beta-enolase while repressing embryo...
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Sox6 belongs to the Sox gene family and plays a pivotal role in fiber type differentiation, suppressing transcription of slow-fiber-specific genes during fetal development. Here, we show that Sox6 plays opposite roles in MyHC-I regulation, acting as a positive and negative regulator of MyHC-I expression during embryonic and fetal myogenesis, respectively. During embryonic myogenesis, Sox6 posit...
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ژورنال
عنوان ژورنال: Developmental Cell
سال: 2010
ISSN: 1534-5807
DOI: 10.1016/j.devcel.2010.03.005